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Updated: Jan 28, 2026

MRI and PET in Mouse Models of Myocardial Infarction
Published on: December 19, 2013
How to detect and correct myocardial creep in myocardial perfusion imaging using Rubidium-82 PET?
S S Koenders1,2, J D van Dijk3, P L Jager3
1Department of Nuclear Medicine, Isala hospital, PO Box 10400, 8000 GK, Zwolle, The Netherlands. skoenders93@gmail.com.
Abstract:
Reliability of myocardial blood flow (MBF) quantification in myocardial perfusion imaging (MPI) using PET can majorly be affected by the occurrence of myocardial creep when using pharmacologically induced stress. In this paper, we provide instructions on how to detect and correct for myocardial creep. For example, in each time frame of the PET images the myocardium contour and the observed activity have to be compared to check for misalignments. In addition, we provide an overview of the functionality of commonly used software packages to perform this quality control step as not all software packages currently provide this functionality. Furthermore, important clinical considerations to obtain accurate MBF measurements are given.
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