Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent gene conversion between genes encoding human red and green visual pigments.

K Kuma1, H Hayashida, T Miyata

  • 1Department of Biology, Faculty of Science, Kyushu University, Fukuoka.

Idengaku Zasshi
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Сarotid artery ultrasonography for diagnosis and monitoring of cervical and intracranial large vessel vasculitis in a patient with systemic lupus erythematosus and Sjögren syndrome.

QJM : monthly journal of the Association of Physicians·2023
Same author

An experimental setup for creating and imaging <sup>4</sup>He<sub>2</sub> <sup>*</sup> excimer cluster tracers in superfluid helium-4 via neutron-<sup>3</sup>He absorption reaction.

The Review of scientific instruments·2020
Same author

Non-magnetic flexible heaters for spin-exchange optical pumping of <sup>3</sup>He and other applications.

The Review of scientific instruments·2016
Same author

Oxidative stress and antibody levels to periodontal bacteria in adults: the Nagasaki Islands study.

Oral diseases·2013
Same author

Porphyromonas gingivalis and Escherichia coli lipopolysaccharide causes resistin release from neutrophils.

Oral diseases·2012
Same author

Pediatrician-recommended use of sports drinks and dental caries in 3-year-old children.

Community dental health·2011
Same journal

MECHANISMS OF SPONTANEOUS MUTAGENESIS IN ESCHERICHIA COLI.

Idengaku zasshi·2018
Same journal

Molecular clock for dating of divergence between animal phyla.

Idengaku zasshi·1995
Same journal

Mitochondrial plasmid-like DNAs of the B1 family in the genus Oryza: sequence heterogeneity and evolution.

Idengaku zasshi·1995
Same journal

Regional localization of rat and mouse protein-tyrosine phosphatase PTP alpha/LRP gene (Ptpra) by fluorescence in situ hybridization.

Idengaku zasshi·1995
Same journal

Polymorphic distribution and molecular diversification of mitochondrial plasmid-like DNAs in the genus Oryza.

Idengaku zasshi·1995
Same journal

Molecular characterization of a family of tandemly repetitive DNA sequences (pYS family) in the genus Hemitaxonus (Hymenoptera: Tenthredinidae).

Idengaku zasshi·1995
See all related articles

Human X-linked red and green pigment genes underwent recent gene conversion, explaining their similarity and red-green color blindness prevalence. This highlights the impact of mutation rates on genetic disorders.

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Human X-linked red and green pigment genes are crucial for color vision.
  • Sequence similarity between these genes is high, suggesting a shared evolutionary history.
  • X-linked genes often exhibit lower mutation rates compared to autosomal genes.

Purpose of the Study:

  • To investigate the evolutionary relationship between human X-linked red and green pigment genes.
  • To determine the timing and impact of gene conversion events on these genes.
  • To understand the role of sequence similarity in the prevalence of red-green color blindness.

Main Methods:

  • Comparative analysis of nucleotide sequences of human X-linked red and green pigment genes.
  • Calculation of silent substitution rates (KSc) between gene pairs.

Related Experiment Videos

  • Comparison with primate gene sequences to infer evolutionary events.

    • Main Results:

    • Gene conversion occurred in red and green pigment genes around the divergence of African apes and orangutans.
    • Recent gene conversion and a slower mutation rate contribute to high sequence similarity.
    • The red pigment gene shows a five-fold faster evolution rate than the green pigment gene post-gene conversion.

    Conclusions:

    • Recent gene conversion and reduced mutation rates in X-linked genes explain high sequence similarity.
    • This similarity likely increases the susceptibility to red-green color blindness in humans.
    • Differential evolution rates suggest distinct selective pressures on red and green pigment genes.