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MIG in Cutaneous Systemic Lupus Erythematosus
1Department of Clinical and Experimental Medicine, University of Pisa, Italy.
La Clinica Terapeutica
|February 22, 2019
Summary
Monokine induced by interferon-gamma (MIG) and its receptor CXCR3 are involved in T cell recruitment in cutaneous lupus erythematosus. Elevated MIG levels correlate with disease activity, suggesting MIG
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Monokine induced by interferon-gamma (MIG) and its receptor CXCR3 are expressed on T cells in cutaneous lupus lesions.
- CXCR3-activating chemokines are produced locally, indicating a role in T cell recruitment to inflammatory sites.
Purpose of the Study:
- To review the evidence for MIG's role in the pathogenesis of cutaneous lupus erythematosus (CLE).
Main Methods:
- Review of existing literature on MIG and CXCR3 in cutaneous lupus.
Main Results:
- Circulating MIG levels are elevated in cutaneous Systemic Lupus Erythematosus (SLE) patients.
- MIG levels strongly correlate with disease activity in cutaneous SLE.
- Evidence suggests MIG participates in the pathogenesis of various cutaneous SLE manifestations.
Conclusions:
- MIG and CXCR3 are implicated in T cell recruitment in cutaneous lupus.
- Elevated MIG levels are associated with increased disease activity in cutaneous SLE.
- Further research is needed to fully elucidate MIG's exact role in cutaneous SLE pathogenesis.
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