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Exportation of MDR TB to Europe from Setting with Actively Transmitted Persistent Strains in Peru

Fermín Acosta, Juan Agapito, Andrea Maurizio Cabibbe

    Emerging Infectious Diseases
    |February 22, 2019
    PubMed

    Insights

    Multidrug-resistant tuberculosis frequently transmits within Peru and spreads to Europe. Global, transnational collaboration is essential to combat this global health threat.

    Area of Science:

    • Molecular epidemiology
    • Infectious disease dynamics
    • Public health surveillance

    Background:

    • Tuberculosis remains a significant global health challenge, particularly multidrug-resistant strains.
    • Understanding transmission patterns is crucial for effective control strategies.
    • Cross-border analyses provide insights into the international spread of infectious diseases.

    Discussion:

    • This study highlights the interconnectedness of tuberculosis transmission across continents.
    • Peru serves as a key origin point for a multidrug-resistant tuberculosis strain that subsequently spread to Europe.
    • The findings underscore the limitations of national-level control efforts for globally mobile pathogens.

    Key Insights:

    • A specific multidrug-resistant tuberculosis strain exhibited significant transmission within Peru.
    • This strain was exported, leading to substantial transmission in Spain and Italy between 2007 and 2017.
    • Molecular epidemiology successfully traced the cross-border dissemination of the resistant strain.

    Outlook:

    • Strengthened international cooperation is imperative for controlling multidrug-resistant tuberculosis.
    • Enhanced global surveillance systems are needed to detect and respond to cross-border transmissions.
    • Future research should focus on targeted interventions to prevent the exportation of resistant strains.
    Keywords:
    EuropeFlorenceItalyLimaMDRMIRU-VNTRMadridMycobacterium tuberculosisPeruSpainantimicrobial resistancebacteriaexportationmigrationmolecular epidemiologymycobacteriumsingle-nucleotide polymorphismspoligotypetransmissiontuberculosistuberculosis and other mycobacteria

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