Related Experiment Video
Updated: Jan 28, 2026
Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
[Granulocytes function in patients with chronic venous insufficiency followed by chronic wounds]
Yu S Vinnik1, G E Karapetyan1, L V Kochetova1
1Voyno-Yasenetsky Krasnoyarsk State Medical University of Healthcare Ministry of the Russia, Krasnoyarsk, Russia.
Aim:
To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency.
Material And Methods:
There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed. De Sole method was used to analyze chemiluminescent and spontaneous activity of neutrophils of peripheral blood.
Results:
Advanced generation of active forms of oxygen was revealed in patients with chronic wounds and chronic venous insufficiency. Complex ozone therapy including intravenous administration of ozonized autologous blood, oxygen-ozone and ultrasonic exposure of the wound and cryogenic stimulation reduce painful period up to 3.1±0.6 days, accelerate epithelialization of the wound and normalize release of active forms of oxygen.
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