Related Experiment Video

Updated: Jan 28, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

Published on: September 30, 2021

7.5K

Impact of Prophylaxis on Bone Mineral Metabolism in Children With Hemophilia

Vildan Culha1, Sibel Akpinar Tekgündüz, Hüsniye N Yarali

  • 1Department of Hematology, Ankara Child Health and Disease, Hematology-Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Journal of Pediatric Hematology/Oncology
|February 22, 2019
PubMed

Insights

Hemophilia patients often have low bone mineral density and vitamin D deficiency. While prophylaxis didn't improve these, monitoring bone turnover markers and bone density is recommended for early detection of bone loss.

Area of Science:

  • Endocrinology
  • Hematology
  • Bone Metabolism

Background:

  • Calcium (Ca) metabolism is crucial for bone health.
  • Hemophilia patients (PWH) may face unique challenges affecting bone metabolism.
  • Early diagnosis and management of metabolic factors are vital.

Purpose of the Study:

  • To investigate calcium metabolism changes in PWH.
  • To assess the impact of diagnosis and treatment on calcium metabolism.
  • To evaluate the significance of early diagnosis and prophylaxis.

Main Methods:

  • Serum levels of calcium, phosphorus, alkaline phosphatase, 25-hydroxy vitamin D (25-OHD), parathormone (PTH), and calcitonin were measured.
  • Bone mineral density (BMD) was assessed using dual-energy x-ray absorptiometry.
  • Patients were analyzed based on prophylaxis status.

Main Results:

  • Low BMD scores (74.4%) and 25-OHD deficiency (87.2%) were prevalent in PWH.
  • Prophylaxis did not significantly alter 25-OHD levels or BMD scores.
  • Higher PTH levels were observed in the prophylaxis group, with a negative correlation to Z-score.

Conclusions:

  • Biochemical markers of bone turnover can aid in detecting bone loss in PWH.
  • Annual BMD measurements and exercise programs are recommended for monitoring and management.
  • Further research with larger cohorts is warranted to confirm findings.

More Related Videos

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.7K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

970

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.3K
Water and Mineral Acquisition02:34

Water and Mineral Acquisition

Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.6K
What is Metabolism?00:52

What is Metabolism?

Overview
131.7K
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.2K
Impact of Groups on Groups01:19

Impact of Groups on Groups

Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
241
Impact01:30

Impact

Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
490