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Updated: Jan 28, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Role of FcγRs in Antibody-Based Cancer Therapy

Robert F Graziano1, John J Engelhardt2

  • 1Oncology Discovery, Bristol-Myers Squibb, Princeton, NJ, Redwood City, CA, USA.

Current Topics in Microbiology and Immunology
|February 22, 2019
PubMed

Insights

Monoclonal antibodies fight tumors directly or by engaging the immune system. The antibody

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Monoclonal antibodies (mAbs) offer versatile therapeutic strategies against cancer.
  • mAbs can directly induce tumor cell death or block tumor growth signals.
  • mAbs can also harness the host immune system for tumor cell destruction.

Purpose of the Study:

  • To explore the multifaceted mechanisms of monoclonal antibody antitumor activity.
  • To highlight the critical role of the Fc portion of antibodies in immune engagement.
  • To review the significance of Fc:FcγR interactions in preclinical and clinical antitumor therapy.

Main Methods:

  • Review of established mechanisms of mAb antitumor action.
  • Discussion of Fc-mediated immune effector functions: complement-mediated cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP).
  • Analysis of mAb-mediated immune system stimulation via immune cell targeting.

Main Results:

  • Antibodies engaging activating Fcγ receptors demonstrate enhanced inhibition of tumor growth and metastasis.
  • Fc:FcγR interactions are crucial for CDC, ADCC, and ADCP.
  • mAbs targeting immune cells can modulate antitumor immunity by altering regulatory or costimulatory signals.

Conclusions:

  • Monoclonal antibodies are potent tools in cancer immunotherapy, acting through diverse mechanisms.
  • The Fc portion of mAbs is essential for mediating immune-dependent antitumor effects.
  • Fc:FcγR interactions represent a key target for optimizing antibody-based cancer therapies.

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