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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
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Neonatal Jaundice.

Pooja Abbey1, Devasenathipathy Kandasamy2, Priyanka Naranje2

  • 1Department of Radio-Diagnosis, Lady Hardinge Medical College, New Delhi, India. pooja_abbey@yahoo.co.in.

Indian Journal of Pediatrics
|February 22, 2019
PubMed
Summary
This summary is machine-generated.

Neonatal hyperbilirubinemia requires timely diagnosis. Imaging like ultrasound and MRCP aids in identifying surgical conditions such as biliary atresia and choledochal cysts, preventing liver damage and brain injury.

Keywords:
Biliary atresiaBilirubin induced brain injuryCholedochal cystNeonatal cholestasis

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Area of Science:

  • Neonatology
  • Pediatric Radiology
  • Hepatology

Background:

  • Neonatal hyperbilirubinemia, both physiological and pathological, is common.
  • Conjugated hyperbilirubinemia can lead to irreversible liver damage if untreated.
  • Severe unconjugated hyperbilirubinemia poses a risk of bilirubin-induced brain injury.

Purpose of the Study:

  • To outline the role of imaging in diagnosing neonatal surgical conditions causing hyperbilirubinemia.
  • To detail imaging features for biliary atresia and choledochal cysts.
  • To describe brain MRI findings in neonatal bilirubin encephalopathy.

Main Methods:

  • Abdominal ultrasound as the first-line imaging modality.
  • Magnetic resonance cholangiopancreatography (MRCP) for pre-operative assessment of choledochal cysts (CDCs).
  • Brain MRI for evaluating bilirubin-induced brain injury.

Main Results:

  • Ultrasound shows 95% sensitivity for biliary atresia using the triangular cord sign and gallbladder abnormalities.
  • MRCP effectively assesses abnormal pancreaticobiliary junction in CDCs.
  • Brain MRI reveals characteristic T1 hyperintensity in acute and T2 hyperintensity in chronic bilirubin encephalopathy.

Conclusions:

  • Timely diagnosis of surgical causes of hyperbilirubinemia is crucial to prevent complications.
  • Imaging modalities like ultrasound and MRCP are vital for diagnosing biliary atresia and CDCs.
  • Prompt evaluation and management of neonatal hyperbilirubinemia are essential to prevent neurological sequelae.