Related Experiment Video
Updated: Jan 28, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.8K
Therapeutic burden in interstitial lung disease: Lessons to learn
Yet H Khor1,2,3,4, Ian Glaspole4,5, Nicole S L Goh1,2,4
1Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC, Australia.
Respirology (Carlton, Vic.)
|February 22, 2019
Summary
Interstitial lung disease (ILD) treatments increase medication complexity and burden. Patients often face polypharmacy and potential drug-disease interactions, especially with corticosteroids, requiring careful management.
Area of Science:
- Pulmonology
- Pharmacology
- Clinical Medicine
Background:
- Patients with interstitial lung disease (ILD) often experience significant treatment burden due to polypharmacy and drug-disease interactions from prescribed therapies.
- This burden is exacerbated by both disease-targeted and symptomatic treatments.
Purpose of the Study:
- To evaluate the complexity of medication regimens in patients with ILD before and after the introduction of ILD-specific therapies.
- To assess potential drug-disease interactions in patients prescribed prednisolone.
Main Methods:
- A study involving 214 patients with ILD, assessing demographic information, comorbidities, and medication use.
- Medication lists were reviewed pre- and post-introduction of ILD-specific therapies.
- Medication regimen complexity was quantified using the Medication Regimen Complexity Index (MRCI).
Main Results:
- Polypharmacy was prevalent at baseline (IPF: 51%, inflammatory ILD: 63%).
- Median MRCI scores significantly increased post-introduction of ILD-specific therapies for both IPF and inflammatory ILD groups (P < 0.0001).
- Among patients on prednisolone (n=113), 88% had comorbidities that could be impacted by the drug, including gastrointestinal diseases, obesity, osteoporosis, and diabetes.
Conclusions:
- Polypharmacy and complex medication regimens are common in patients with ILD across various etiologies.
- A high frequency of potential drug-disease interactions exists, particularly with systemic corticosteroid use.
- Findings underscore the necessity of carefully evaluating the impact of therapeutic complexity and burden in ILD patients.
Related Concept Videos
01:47Lung Capacity
56.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.2K
01:14Avoidance Learning and Learned Helplessness
2.6K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.6K
01:13Therapeutic Index
6.7K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
01:27Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
01:22Purposive Learning
470
E. C. Tolman emphasized the purposiveness of behavior — the idea that much of our behavior is goal-directed. For instance, employees who aim for a promotion work diligently to meet their targets. Tolman argued that when classical conditioning and operant conditioning occur, the organism acquires certain expectations. In classical conditioning, a child might fear a dog because they expect it to bite. In operant conditioning, a person might consistently work overtime because they expect a...
470
01:12Observational Learning
893
Albert Bandura's observational learning, also known as imitation or modeling, occurs when a person observes and imitates another's behavior. It is a quicker process than operant conditioning. A well-known example is the Bobo doll study, where children who saw an adult acting aggressively towards the doll were more likely to act aggressively when left alone, compared to those who observed a nonaggressive adult. Many psychologists view observational learning as a form of latent learning...
893