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Updated: Jan 28, 2026

Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
Published on: January 26, 2024
Human cancer, the naked mole rat and faunal turnovers
Anders Bredberg1, Birger Schmitz2
1Department of Laboratory Medicine, Lund University, Lund, Sweden.
Abstract:
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.
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