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Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Cardiac Output and Stroke Volume01:11

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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
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Translation01:31

Translation

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Gap Junctions01:37

Gap Junctions

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Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
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Gap Junctions01:27

Gap Junctions

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The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
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Diagnostic performance of prehospital large-vessel occlusion detection scales in patients with suspected acute stroke: a retrospective validation study. The Akershus Study of Ischemic Stroke and Thrombolysis.

European stroke journal·2026
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Cryptogenic stroke in women: impact of insertable cardiac monitoring in the STROKEWISE cohort study.

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Association between blood pressure and outcome in patients with acute ischemic stroke treated with alteplase.

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Related Experiment Video

Updated: Jan 28, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

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The knowing-doing gap in acute stroke-Does stroke knowledge translate into action?

Kashif W Faiz1,2, Antje Sundseth1, Bente Thommessen1

  • 1Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

Brain and Behavior
|February 22, 2019
PubMed
Summary
This summary is machine-generated.

Healthcare professionals show a significant knowing-doing gap in acute stroke care. Increased knowledge about stroke symptoms did not correlate with faster hospital admissions for patients.

Keywords:
knowledgeprehospital delayrisk factorsstrokethrombolysis

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Area of Science:

  • Neurology
  • Emergency Medicine
  • Health Services Research

Background:

  • Acute stroke management requires timely intervention.
  • A gap often exists between medical knowledge and clinical practice.

Purpose of the Study:

  • To investigate the relationship between stroke knowledge and hospital admission times.
  • To identify potential barriers in acute stroke care.

Main Methods:

  • Assessed stroke knowledge levels among healthcare providers.
  • Analyzed the time from symptom onset to hospital admission.
  • Correlated stroke knowledge scores with admission timelines.

Main Results:

  • Higher stroke knowledge was not associated with earlier hospital admission.
  • Indicates a disconnect between knowing stroke protocols and implementing them promptly.

Conclusions:

  • A substantial knowing-doing gap persists in acute stroke care.
  • Further research is needed to address barriers to timely stroke treatment.