The relationship between MMP9 and ADRA2A gene polymorphisms and mothers-newborns' nutritional status: an exploratory...

Area of Science:

• Genetics and Genomics
• Obstetrics and Gynecology
• Perinatology

Background:

• Maternal weight gain and newborn birth weight are critical indicators of pregnancy health.
• Genetic factors, including polymorphisms in matrix metalloproteinase (MMP9) and adrenergic receptor (ADRA2A) genes, may influence these outcomes.
• Understanding these genetic influences is crucial for identifying potential risks and improving maternal and infant health.

Purpose of the Study:

• To investigate the direct impact of specific gene polymorphisms (MMP9 rs17577, MMP9 rs17576, ADRA2A rs553668) in mothers and newborns on maternal weight gain and birth weight.
• To assess the association of these genetic variations with other relevant factors affecting pregnancy outcomes.

Main Methods:

• A cross-sectional study was conducted involving 197 mother-newborn pairs.
• Demographic, anthropometric, and gene polymorphism data were collected and analyzed.
• Statistical analyses were performed to determine correlations and influences.

Main Results:

• Newborn birth weight was positively correlated with maternal age and educational level, and negatively with maternal smoking.
• Maternal genotypes of MMP9 rs17577 and ADRA2A rs553668 were associated with lower and higher birth weights, respectively.
• Newborn genotypes of MMP9 rs17577 and MMP9 rs17576 showed significant positive and negative correlations with birth weight, respectively.

Conclusions:

• The study highlights the significant role of MMP9 rs17577, MMP9 rs17576, and ADRA2A rs553668 single nucleotide polymorphisms (SNPs) in determining newborn birth weight.
• These findings contribute to understanding the genetic underpinnings of birth weight variations.
• Further research is warranted to explore the clinical implications of these genetic associations.