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Updated: Jan 28, 2026

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
Published on: January 10, 2025
Regulation of leukocyte function by citric acid cycle intermediates
Naeem K Patil1, Julia K Bohannon1,2, Antonio Hernandez1
1Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Abstract:
Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions.
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