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Updated: Jan 28, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
New Insights into the Role of Epithelial⁻Mesenchymal Transition during Aging
Francisco Santos1, Cristiana Moreira2, Sandrina Nóbrega-Pereira3,4
1Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal. franciscojfsantos@ua.pt.
Abstract:
Epithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
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