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Updated: Jan 28, 2026

Murine Model of Wound Healing
Published on: May 28, 2013
Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside
Ruilong Zhao1, Haiyan Lin2, Lara Bereza-Malcolm3
1Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia. rzha9073@uni.sydney.edu.au.
Abstract:
Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing-a complex process involving inflammation, proliferation and remodelling. This review will highlight APC's functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.
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