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Molecular aspects of reovirus-host cell interaction
J A Cohen1, W V Williams, M I Greene
1Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Microbiological Sciences
|September 1, 1988
Summary
Reovirus cell attachment is dictated by the sigma 1 protein. This protein interacts with cell receptors, influencing viral tropism, virulence, and host cell growth inhibition.
Area of Science:
- Virology
- Molecular Biology
- Cell Biology
Background:
- Reovirus biology is primarily characterized by its outer capsid sigma 1 protein.
- The sigma 1 protein mediates viral attachment to host cells.
Purpose of the Study:
- To elucidate the role of the sigma 1 protein in reovirus tropism and virulence.
- To understand how sigma 1 interaction with cell receptors affects viral pathogenesis and host cell functions.
Main Methods:
- Analysis of reovirus sigma 1 protein structure and function.
- Investigating the interaction between sigma 1 and host cell surface receptors.
- Assessing the impact of sigma 1-receptor binding on viral tropism and virulence.
Main Results:
- The sigma 1 protein is the key determinant of reovirus cell attachment.
- Specific interactions between sigma 1 and serotype-specific cell receptors govern viral tropism.
- Sigma 1 binding to receptors mediates viral inhibition of target cell growth, impacting virulence.
Conclusions:
- The sigma 1 protein is central to reovirus pathogenesis.
- Targeting sigma 1-receptor interactions offers potential strategies for controlling reovirus infections.
- Understanding these interactions is crucial for deciphering reovirus-host cell dynamics.