A transannular approach toward lycopodine synthesis
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Updated: Jan 28, 2026

Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Michaela C Vertorano1, Kyla L Johnson1, Ping He1
1Department of Chemistry, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY, 12222, USA.
Abstract:
A transannular reaction was proposed to access the Lycopodium alkaloid lycopodine. A key bicyclic precursor was synthesized via a ring-closing metathesis reaction. Initial evaluations of the transannular aza-Prins reaction to synthesize lycopodine were reported and discussed.
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