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Updated: Jan 28, 2026
10:53
Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
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π-π Stacking Mediated Chirality in Functional Supramolecular Filaments
Myungshim Kang1, Pengcheng Zhang2, Honggang Cui3,2
1Department of Chemistry, College of Staten Island, The City University of New York, 2800 Victory Boulevard, Staten Island, New York 10314, United States.
Macromolecules
|February 23, 2019
Summary
Chiral filaments form from peptide-drug conjugates, with aromatic drug stacking driving assembly. Hydrogen bonds stabilize the structure later, guiding supramolecular design.
Area of Science:
- Supramolecular chemistry
- Computational chemistry
- Materials science
Background:
- Peptide-based supramolecular filaments are diverse.
- The role of auxiliary segments in chiral peptide assembly is unclear.
Purpose of the Study:
- Investigate chiral filament formation in peptide-drug conjugates.
- Understand the influence of aromatic drug moieties on self-assembly.
Main Methods:
- Computational study of self-assembly.
- Analysis of intermolecular interactions (π–π stacking, hydrogen bonding).
Main Results:
- Chirality is primarily mediated by π–π stacking between camptothecin (CPT) molecules.
- CPT stacking dictates early assembly stages; hydrogen bonding influences later morphology.
- Water molecules may be present within the filament core.
Conclusions:
- Aromatic segment interactions are crucial for chiral supramolecular assembly.
- Findings offer guidance for designing peptide conjugates with specific self-assembly properties.
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