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Beyond KRAS: Practical Molecular Targets in Pancreatic Adenocarcinoma

Albert Grinshpun1, Yonaton Zarbiv1, Jason Roszik2

  • 1Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Case Reports in Oncology
|February 23, 2019
PubMed

Insights

Pancreatic cancer (PDAC) rarely has KRAS wildtype. Three metastatic PDAC patients with KRAS wildtype harbored BRAF or RET alterations and received targeted therapies with varied outcomes, suggesting further research is warranted.

Area of Science:

  • Oncology
  • Genomics
  • Translational Research

Background:

  • Pancreatic adenocarcinoma (PDAC) typically exhibits KRAS mutations, limiting targeted treatment options.
  • A small subset of PDAC patients present with KRAS wildtype tumors, suggesting alternative driver mutations.
  • Identifying these alternative drivers is crucial for developing novel therapeutic strategies.
Keywords:
BRAFKRASPancreatic adenocarcinomaRETTargeted therapy

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