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A Mosquito Bite with Devastating Complications in an Immunocompromised Patient
Jochen J Frietsch1, Nils Winkelmann1, Friederike Hunstig1
1Klinik für Innere Medizin II, Hämatologie und internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.
Abstract:
Infectious complications such as invasive aspergillosis or infection with Stenotrophomonas maltophilia (SM) in immunocompromised patients are associated with a high mortality rate. Our report concerns a 40-year-old male newly diagnosed very severe aplastic anemia (vSAA) who in consequence of a mosquito bite was suffering from skin lesion and consecutive soft tissue phlegmon subsequent to the administration of antithymocyte globulin; a full-thickness autologous meshed skin graft successfully performed to cover skin ulcera after allogeneic stem cell transplantation (SCT). This unusual case illustrates the importance of appropriate diagnosis, anti-infective therapy and close interdisciplinary diagnostic algorithms to minimalize side effects and the selection of resistant strains and to improve patients' outcome.
Insights
This case study highlights a rare skin infection in a patient with very severe aplastic anemia (vSAA). Prompt diagnosis and treatment of the soft tissue phlegmon were crucial for successful recovery post-stem cell transplantation (SCT).
Area of Science:
- Hematology
- Infectious Diseases
- Dermatology
Background:
- Immunocompromised patients face high mortality risks from infections like invasive aspergillosis or Stenotrophomonas maltophilia (SM).
- Very severe aplastic anemia (vSAA) requires intensive treatment, including allogeneic stem cell transplantation (SCT), which further increases infection susceptibility.
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