Are iris mammillations correlated with keratoconus?
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Updated: Jan 28, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Rosalia M S Antunes-Foschini1, Roberta Martins S Costa2, Sidney Júlio Faria-E-Sousa3
1Hospital das Clínicas, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Purpose:
To describe the presence of iris mammillations (IM) in keratoconus.
Design:
Retrospective case series and literature review.
Observations:
This is a retrospective case series of eight patients presenting with keratoconus and IM, who were examined between January 2016 and December 2017 in the ophthalmology outpatient clinic. They had a median age of 14 (11-30), and all had bilateral keratoconus and diffusely distributed IM. The IM had similar presentations and similar iris colors. None had relevant medical or family diseases associated with IM. Three eyes previously had penetrating keratoplasty. Four (31%) out of 13 eyes had mean keratometry (Km) > 55D, and 4 (31%) had the thinnest pachymetry between 300 and 400μm.
Conclusions And Importance:
To the best of our knowledge this is the first time that IM was observed in association with keratoconus patients. The possibility that IM is an early finding in otherwise healthy patients may help to predict the future diagnosis of keratoconus. Future studies are needed to show the frequency and possible association between IM and a keratoconus prognosis. This may also demonstrate that there is a subgroup of patients with a distinct etiology of keratoconus.
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