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Published on: September 3, 2012
Female genital tract chronic graft-versus-host disease: A narrative review
Andréa Maria Novaes Machado1, Nelson Hamerschlak1, Morgani Rodrigues1
1Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Abstract:
Graft-versus-host disease is one of the main causes of morbidity and mortality in patients submitted to hematopoietic stem cell transplantation. This study reviewed the prevalence of lower female genital tract graft-versus-host disease following hematopoietic stem cell transplantation. A systematic search of the literature for articles published between 1982 and 2015 was performed. A growing number of young women suffering from malignant and benign hematological diseases are receiving allogeneic hematopoietic stem cell transplantation with very satisfactory results in relation to the disease itself. However, these patients face gynecological problems due to graft-versus-host disease. Correct diagnosis and early management are needed to avoid irreversible complications.
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