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MEG3: an Oncogenic Long Non-coding RNA in Different Cancers
Arwa Al-Rugeebah1, Mohammed Alanazi1, Narasimha Reddy Parine2
1Genome Research Chair, College of Science, King Saud University, Riyadh, Saudi Arabia.
Pathology Oncology Research : POR
|February 23, 2019
Summary
Long noncoding RNA (lncRNA) MEG3 functions as a tumor suppressor by regulating key cancer genes and pathways. Its deregulation is linked to cancer progression, highlighting its potential as a biomarker and therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Long noncoding RNAs (lncRNAs) are key regulators of biological processes, including tumorigenesis.
- Some lncRNAs act as oncogenes or tumor suppressors in cancer.
- Maternally expressed gene 3 (MEG3) is a lncRNA with demonstrated antitumor properties across various cancer types.
Purpose of the Study:
- To review the biological functions of MEG3 in repressing tumor growth.
- To explore MEG3's mechanisms in regulating tumor suppressor genes, angiogenesis, and microRNAs.
- To discuss MEG3's role in epithelial-mesenchymal transition (EMT) and its potential as a cancer biomarker and therapeutic target.
Main Methods:
- Literature review of studies on MEG3 function in cancer.
- Analysis of MEG3's regulatory roles in major tumor suppressor pathways (p53, Rb).
- Investigation of MEG3's impact on angiogenesis and microRNA networks.
Main Results:
- MEG3 exhibits antitumor activity in breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian, and osteosarcoma cells.
- MEG3 represses tumors by regulating p53, Rb, angiogenesis factors, and microRNAs.
- MEG3 is implicated in mediating epithelial-mesenchymal transition (EMT).
Conclusions:
- Deregulation of MEG3 is associated with cancer development and progression.
- MEG3 functions as a crucial tumor suppressor.
- MEG3 holds potential as a biomarker and therapeutic target for human cancers.
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