Related Experiment Video

Updated: Jan 28, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Association between fetuin-A and prognosis of CAD: A systematic review and meta-analysis

Wei-Ming Xie1,2,3, Lu-Sen Ran2, Jie Jiang2

  • 1Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

European Journal of Clinical Investigation
|February 23, 2019
PubMed

Insights

High serum fetuin-A levels are linked to reduced mortality in coronary artery disease (CAD) patients. This meta-analysis found no significant association between fetuin-A and secondary cardiovascular disease events in CAD.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Research

Background:

  • Fetuin-A acts as an anti-inflammatory and anti-calcification factor.
  • Its role in coronary artery disease (CAD) prognosis remains debated.
  • Clarifying fetuin-A's prognostic value in CAD is crucial.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between serum fetuin-A levels and CAD patient prognosis.
  • To evaluate the impact of fetuin-A on all-cause mortality and secondary cardiovascular disease (CVD) events.

Main Methods:

  • Systematic review and meta-analysis of prospective studies published before January 2019.
  • Included studies focused on patients with diagnosed CAD.
  • Hazard ratios (HR) or Kaplan-Meier curves for mortality and CVD events were analyzed.

Main Results:

  • Four studies with 4256 CAD participants were analyzed.
  • High serum fetuin-A was significantly associated with lower all-cause mortality (HR: 0.57, 95% CI: 0.37-0.87).
  • No significant association was found between serum fetuin-A and secondary CVD events (HR: 0.86, 95% CI: 0.60-1.23).

Conclusions:

  • Elevated serum fetuin-A levels correlate with improved survival in CAD patients.
  • Serum fetuin-A levels do not appear to predict the incidence of secondary CVD events in CAD.
  • Fetuin-A may serve as a potential prognostic biomarker for CAD mortality.
Abstract

Keywords:
all-cause mortalitycoronary artery diseasefetuin-Ameta-analysisprognosissecondary CVD incidence

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

77.4K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.8K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.9K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.0K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.2K