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Updated: Jan 28, 2026
Interview: Bioreactors and Surfaced-Modified 3D-Scaffolds for Stem Cell Research
Published on: May 21, 2008
3D Scaffolds to Study Basic Cell Biology
Marc Hippler1,2, Enrico Domenico Lemma1, Sarah Bertels1,3
1Zoological Institute, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 4, 76131, Karlsruhe, Germany.
Abstract:
Mimicking the properties of the extracellular matrix is crucial for developing in vitro models of the physiological microenvironment of living cells. Among other techniques, 3D direct laser writing (DLW) has emerged as a promising technology for realizing tailored 3D scaffolds for cell biology studies. Here, results based on DLW addressing basic biological issues, e.g., cell-force measurements and selective 3D cell spreading on functionalized structures are reviewed. Continuous future progress in DLW materials engineering and innovative approaches for scaffold fabrication will enable further applications of DLW in applied biomedical research and tissue engineering.
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