Related Experiment Video
Updated: Jan 28, 2026

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion
Published on: April 21, 2023
The minimum clinically important difference: which direction to take
T H P Draak1, B T A de Greef1,2, C G Faber1
1Department of Neurology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Abstract:
Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum clinically important difference (MCID). In this paper, an overview is presented of the most important aspects of the MCID concept used in research trials and a discussion of what this means for the neurological patient in clinical trials and daily practice is given. Is the MCID the best outcome measure cut-off to be implemented?
Related Concept Videos
Electric Potential and Potential Difference
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Identifying Statistically Significant Differences: The F-Test
Sum and Difference OpAmps
A summing amplifier, or an adder, utilizes an op-amp to merge multiple input signals into a single output signal. When audio signals are introduced into its input channels, the input resistors initiate currents that traverse feedback resistors, resulting in an output voltage. Applying Kirchhoff's current...
Difference Equation Solution using z-Transform
The z-transform facilitates handling delayed signals by shifting the signal in the z-domain, which corresponds to delaying the signal in the time domain, and advancing signals by similarly shifting in the...
Directing Effect of Substituents: meta-Directing Groups

