Related Experiment Video
Updated: Jan 28, 2026
14:22
Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
20.8K
Dynamic Synthetic Biointerfaces: From Reversible Chemical Interactions to Tunable Biological Effects
Accounts of Chemical Research
|February 23, 2019
Summary
Researchers developed novel dynamic synthetic biointerfaces that use noninvasive biological stimuli to control cell behaviors. These smart biomaterials offer tunable interactions for applications in tissue engineering and cancer theranostics.
Area of Science:
- Biomaterials Science
- Chemical Biology
- Cell Biology
Background:
- Dynamic synthetic biointerfaces mimic the extracellular matrix (ECM) for controlled cell interactions.
- Current methods often use invasive stimuli and primarily focus on cell adhesion.
- A need exists for biointerfaces that noninvasively control diverse cell behaviors.
Purpose of the Study:
- To develop novel dynamic synthetic biointerfaces using noninvasive stimuli.
- To demonstrate control over various cell behaviors beyond adhesion.
- To explore applications in tissue engineering and cancer theranostics.
Main Methods:
- Utilized reversible covalent bonds, metal coordinative interactions, and molecularly imprinted synthetic receptors.
- Incorporated biological stimuli like pH, temperature, and specific biomolecules.
- Investigated control of cell adhesion, differentiation, and apoptosis.
Main Results:
- Successfully fabricated biointerfaces responsive to biological stimuli.
- Demonstrated noninvasive control over cell adhesion, differentiation, and apoptosis.
- Conceptually showed potential for nanobiointerfaces and diverse applications.
Conclusions:
- Dynamic synthetic biointerfaces offer tunable control over cell behaviors using noninvasive methods.
- These advanced biomaterials have significant potential in fundamental cell biology, tissue engineering, and cancer theranostics.
- Further development will bridge chemistry and biology for innovative biomedical solutions.
Related Concept Videos
02:55Synthetic Biology
5.6K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
5.6K
02:59Biological Effects of Radiation
17.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
01:27Effects of Chemicals: Overview
2.2K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
2.2K
01:08Types of Chemical Reactions: Exchange and Reversible
10.7K
An exchange reaction is a chemical reaction in which both synthesis and decomposition occur, chemical bonds are both formed and broken, and chemical energy is absorbed, stored, and released.
A special kind of exchange reaction is the oxidation-reduction reaction, or the redox reaction. These reactions involve the transfer of electrons from one compound to another. The electrons in these reactions commonly come from hydrogen atoms, which consist of an electron and a proton. A molecule gives up a...
A special kind of exchange reaction is the oxidation-reduction reaction, or the redox reaction. These reactions involve the transfer of electrons from one compound to another. The electrons in these reactions commonly come from hydrogen atoms, which consist of an electron and a proton. A molecule gives up a...
10.7K
02:20Dynamic Equilibrium
62.4K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.4K
01:27Inductive Effects on Chemical Shift: Overview
2.2K
The protons in unsubstituted alkanes are strongly shielded with chemical shifts below 1.8 ppm. Methine, methylene, and methyl protons appear at approximately 1.7, 1.2 and 0.7 ppm, while the proton signal from methane appears at 0.23 ppm. An electronegative substituent, such as chlorine, withdraws the electron density from the protons, increasing their chemical shift. Progressive substitution of the hydrogens in methane by chlorine shifts the proton signals increasingly downfield, to 3.05 ppm in...
2.2K