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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
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Necrotizing enterocolitis
Jenny Bellodas Sanchez1, Mark Kadrofske2
1Neonatal-Perinatal Medicine Fellowship Program, Michigan State University and Sparrow Hospital, Lansing, Michigan.
Neurogastroenterology and Motility
|February 23, 2019
Summary
Necrotizing enterocolitis (NEC) in preterm infants is linked to reduced vagal tone and impaired nerve function. This study highlights the role of the enteric nervous system in NEC, suggesting new diagnostic avenues.
Area of Science:
- Neonatal research
- Gastroenterology
- Neuroscience
Background:
- Necrotizing enterocolitis (NEC) is a critical intestinal disease in preterm infants, posing significant morbidity and mortality risks.
- Distinguishing NEC early in preterm infants is challenging, necessitating reliable biomarkers.
- Emerging evidence suggests the enteric nervous system plays a role in NEC pathogenesis.
Purpose of the Study:
- To investigate the association between NEC and the enteric nervous system, specifically vagal tone and neurotransmission.
- To explore potential neurogastroenterological biomarkers for NEC.
Main Methods:
- Utilized a rodent model to study NEC.
- Assessed vagal tone via high-frequency heart rate variability (HF-HRV).
- Examined myenteric nitrergic inhibitory neurotransmission.
Main Results:
- NEC was associated with diminished vagal tone, indicated by decreased HF-HRV.
- Altered myenteric nitrergic inhibitory neurotransmission was observed in the NEC model.
- Findings align with previous studies showing decreased HF-HRV in human infants with NEC.
Conclusions:
- The enteric nervous system, particularly vagal tone and neurotransmission, is implicated in NEC.
- Neurogastroenterological factors may serve as potential biomarkers for NEC diagnosis and management.
