Related Experiment Video

Updated: Jan 28, 2026

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

967

Systemic treatment of advanced hepatocellular cancer: new hope on the horizon

Rachael Chang Lee1, Niall Tebbutt1

  • 1a Department of Medical Oncology , Olivia Newton-John Cancer Wellness and Research Centre , Heidelberg , Australia.

Expert Review of Anticancer Therapy
|February 23, 2019
PubMed
Abstract

Insights

New targeted therapies have significantly improved outcomes for advanced hepatocellular carcinoma (HCC) patients. Sequential treatments combining targeted agents and immunotherapy offer better prognoses for advanced HCC, with ongoing research into novel combinations and personalized medicine.

Area of Science:

  • Hepatology
  • Oncology
  • Pharmacology

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality globally.
  • Many patients are diagnosed at advanced stages, precluding locoregional treatments.
  • Sorafenib was the sole treatment for advanced HCC for many years.

Purpose of the Study:

  • To review current systemic treatment options for advanced HCC in patients ineligible for locoregional therapy.
  • To discuss future prospects in advanced HCC management.

Main Methods:

  • This is a review article.
  • It summarizes current systemic therapies and future directions.
  • Expert opinion is included.

Main Results:

  • New targeted therapeutics have transformed advanced HCC treatment.
  • Sequential therapies (sorafenib/lenvatinib first-line, immunotherapy/regorafenib/cabozantinib second-line) improve outcomes.
  • Novel combinations and biomarkers are under investigation.

Conclusions:

  • Advanced HCC treatment has significantly improved due to new systemic therapies.
  • Personalized treatment approaches considering etiology and molecular factors are crucial.
  • Further research into novel combinations and biomarkers is warranted.
Keywords:
Hepatocellular cancerbiomarkersfuture researchimmunotherapymolecular targeted agentssystemic treatment

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