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Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines
Susan C Gilchrist1,2, Michael Roth3, J Andrew Livingston3,4
11 Department of Clinical Cancer Prevention and Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Abstract:
Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction. There was a significant change in E-wave velocity (p = 0.04). To our knowledge, this is the first study assessing short-term change in systolic and diastolic function in osteosarcoma patients receiving anthracyclines.
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