Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Long-term Depression01:03

Long-term Depression

3.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.3K
Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

484
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
484
Short-distance Transport of Resources02:12

Short-distance Transport of Resources

17.6K
Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
17.6K
Power System Three-Phase Short Circuits01:21

Power System Three-Phase Short Circuits

551
Determining the subtransient fault current in a power system involves representing transformers by their leakage reactances, transmission lines by their equivalent series reactances, and synchronous machines as constant voltage sources behind their subtransient reactances. In this analysis, certain elements are excluded, such as winding resistances, series resistances, shunt admittances, delta-Y phase shifts, armature resistance, saturation, saliency, non-rotating impedance loads, and small...
551
Regional Terms01:12

Regional Terms

15.4K
Regional terms describe anatomy by dividing the body parts into different regions that contain structures involved in contributing similar functions. Using these terms helps increase the accurate description and identification of the particular region of interest or region affected by the disease.
Primarily, the human body has two major regions, the axial and appendicular regions. The axial region comprises regions from the head to the abdomen and makes up the central body axis. In contrast,...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early anthracycline cardiotoxicity in adolescents and young adults with sarcoma: a prospective echocardiographic study.

ESC heart failure·2026
Same author

An international framework for clinical translation of molecular classifiers in osteosarcoma.

NPJ precision oncology·2026
Same author

Physical Activity Monitoring in Adolescents and Young Adults With Cancer: Observational Feasibility Study.

JMIR cancer·2026
Same author

Potential biomarkers and preventative interventions for muscle wasting in adolescent and young adults with cancer: A translational study.

Scientific reports·2026
Same author

Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement From the American Society of Echocardiography Developed in Collaboration With the European Association of Cardiovascular Imaging of the European Society of Cardiology.

European heart journal. Cardiovascular Imaging·2026
Same author

Development of a Multidisciplinary Adolescent and Young Adult Program at a Large Academic Cancer Center.

JCO oncology practice·2026

Related Experiment Video

Updated: Jan 28, 2026

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

1.5K

Short-Term Changes in Cardiac Function in Osteosarcoma Patients Receiving Anthracyclines.

Susan C Gilchrist1,2, Michael Roth3, J Andrew Livingston3,4

  • 11 Department of Clinical Cancer Prevention and Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Journal of Adolescent and Young Adult Oncology
|February 23, 2019
PubMed
Summary

High-dose anthracyclines for osteosarcoma significantly reduce cardiac function, including left ventricular ejection fraction, within two years in young survivors. This study highlights early cardiac changes in adolescent and young adult cancer patients.

Keywords:
adolescent and young adult cancer survivorsanthracyclinescardiac functionosteosarcoma

More Related Videos

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K
C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
09:58

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays

Published on: March 11, 2011

30.4K

Related Experiment Videos

Last Updated: Jan 28, 2026

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

1.5K
Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K
C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
09:58

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays

Published on: March 11, 2011

30.4K

Area of Science:

  • Cardiology
  • Oncology
  • Pediatric Medicine

Background:

  • Long-term cardiac effects of anthracyclines are known, but short-term changes in adolescents and young adults are understudied.
  • Osteosarcoma treatment often involves high-dose anthracyclines, posing risks to cardiac health.

Purpose of the Study:

  • To evaluate short-term changes in cardiac function within two years after high-dose anthracycline treatment for osteosarcoma.
  • To assess both systolic and diastolic function in this vulnerable patient group.

Main Methods:

  • Prospective evaluation of 18 patients treated with high-dose anthracyclines for osteosarcoma.
  • Cardiac function assessment conducted within a two-year follow-up period.

Main Results:

  • A significant decline in left ventricular ejection fraction (p=0.005) was observed at two years.
  • Eight out of 18 patients experienced a reduction greater than 10% in ejection fraction.
  • Significant changes in E-wave velocity (p=0.04), indicating diastolic dysfunction, were noted.

Conclusions:

  • High-dose anthracyclines cause significant short-term cardiac dysfunction in young osteosarcoma patients.
  • Early monitoring of cardiac function is crucial for survivors of anthracycline chemotherapy.
  • This study is the first to document these rapid changes in systolic and diastolic function.