Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

82.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.8K
Encoding01:19

Encoding

837
Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
837
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.2K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.2K
Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
What is Population Genetics?01:25

What is Population Genetics?

64.7K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LP2, a stable lanthipeptide derived from cAng-(1-7), exerts myeloprotective action in mice.

European journal of haematology·2023
Same author

Biosynthesis of lanthionine-constrained agonists of G protein-coupled receptors.

Biochemical Society transactions·2020
Same author

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

Molecular medicine (Cambridge, Mass.)·2020
Same author

High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB.

ACS synthetic biology·2020
Same author

Phage display and selection of lanthipeptides on the carboxy-terminus of the gene-3 minor coat protein.

Nature communications·2017
Same author

Semi-microbiological synthesis of an active lysinoalanine-bridged analog of glucagon-like-peptide-1.

Peptides·2017
Same journal

Kinetic and Spatial Resolution by dSTORM of miniSOG-Mediated Proximity Labeling in Mammalian Cells.

Chembiochem : a European journal of chemical biology·2026
Same journal

Trylons: Polyamide Surrogate Substrates Enable High-Throughput Screening of Nylon-Degrading Enzymes.

Chembiochem : a European journal of chemical biology·2026
Same journal

Membrane-Associated Biomolecules for Synthetic Cell Signalling.

Chembiochem : a European journal of chemical biology·2026
Same journal

Hybrid Aminoferrocenes With Nitrate Esters for In Situ Peroxynitrite Generation: Complex Interplay Between Redox Chemistry, NO-Donor Reactivity, and Aminoferrocene Activation Influences In Vitro Anticancer Activity.

Chembiochem : a European journal of chemical biology·2026
Same journal

Towards the Enzymatic Labeling of Oligonucleotides With Triantennary N-Acetyl Galactosamine.

Chembiochem : a European journal of chemical biology·2026
Same journal

Structure and Activity of Class II Lanthipeptides From a Thermophilic Bacterium.

Chembiochem : a European journal of chemical biology·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

18.8K

Genetically Encoded Libraries of Constrained Peptides.

Tjibbe Bosma1, Rick Rink1, Markus A Moosmeier2

  • 1Lanthio Pharma, a MorphoSys AG Company, Rozenburglaan 13B, 9727 DL, Groningen, The Netherlands.

Chembiochem : a European Journal of Chemical Biology
|February 23, 2019
PubMed
Summary
This summary is machine-generated.

Constrained peptides offer improved therapeutic properties. Genetically encoded display systems, especially for lanthipeptides, accelerate the discovery of these enhanced peptides for drug development.

Keywords:
cysteinedisplaylanthipeptidespeptidomimeticsphage display

More Related Videos

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

7.4K
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

8.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

18.8K
Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein
08:04

Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein

Published on: December 20, 2017

7.4K
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

8.2K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Drug Discovery

Background:

  • Therapeutic peptides often require enhancements in specificity, affinity, stability, and delivery.
  • Conformational constraints are a key modification strategy to improve peptide properties.
  • Genetically encoded libraries are crucial for efficient screening of constrained peptides.

Purpose of the Study:

  • To provide an overview of display systems for genetically encoded constrained peptides.
  • To highlight recent advances in bacterial, phage, and yeast display systems.
  • To discuss the potential of these systems for in vivo applications.

Main Methods:

  • Review of existing literature on display systems for constrained peptides.
  • Focus on ribosomally synthesized and post-translationally modified peptides, including lanthipeptides.
  • Analysis of screening technologies utilizing bacterial, phage, and yeast display.

Main Results:

  • Display systems significantly facilitate the screening and identification of constrained peptides.
  • Bacterial, phage, and yeast display platforms are effective for generating and selecting constrained peptides.
  • Lanthipeptide display systems show particular promise due to their unique structural features.

Conclusions:

  • Display systems are essential tools for advancing constrained peptide therapeutics.
  • Phage and bacterial display systems hold significant promise for in vivo applications.
  • Further development of these systems will accelerate the discovery of novel peptide-based drugs.