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5-FU/leucovorin: biochemical modulation that works?
1Dept. of Surgical Oncology, State U of NY, Buffalo.
Oncology (Williston Park, N.Y.)
|April 1, 1987
Summary
Currently, three Phase III studies are evaluating fluorouracil (5-FU) plus leucovorin. Until results are available, this combination is investigational and not recommended for routine use.
Area of Science:
- Oncology
- Clinical Trials
- Pharmacology
Background:
- Fluorouracil (5-FU) is a common chemotherapy agent.
- Leucovorin is often used to enhance 5-FU efficacy.
- The combination of 5-FU plus leucovorin (CF) is under investigation.
Purpose of the Study:
- To assess the therapeutic utility of 5-FU plus leucovorin in Phase III randomized trials.
- To provide definitive conclusions on the efficacy of the CF combination.
Main Methods:
- Accruing patients to randomized Phase III studies.
- Utilizing cooperative group clinical trial designs.
Main Results:
- Data collection is ongoing from three cooperative groups.
- Definitive conclusions regarding therapeutic utility are pending.
Conclusions:
- The combination of 5-FU plus leucovorin (CF) is currently investigational.
- Routine use of CF is not recommended outside of clinical trials at this time.