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Updated: Jan 28, 2026
05:30
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
29.6K
CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.
Mary T Joy1, Einor Ben Assayag2, Dalia Shabashov-Stone3
1Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Cell
|February 23, 2019
Summary
CCR5 signaling plays a key role in brain repair after stroke and traumatic brain injury (TBI). Targeting CCR5 promotes neural recovery and enhances neurological and cognitive function post-injury.
Area of Science:
- Neuroscience
- Molecular Biology
- Regenerative Medicine
Background:
- CCR5 signaling is a newly identified molecular system.
- CCR5 is uniquely expressed in cortical neurons following stroke.
- Investigating CCR5's role in neural recovery is crucial.
Purpose of the Study:
- To determine the role of CCR5 signaling in recovery after stroke and traumatic brain injury (TBI).
- To evaluate CCR5 as a potential therapeutic target for neural repair.
Main Methods:
- Neuronal knockdown of CCR5 in pre-motor cortex post-stroke.
- Administration of a CCR5 antagonist.
- Analysis of clinical cohort data for CCR5-Δ32 mutation carriers.
Main Results:
- CCR5 knockdown accelerated motor control recovery post-stroke.
- CCR5 antagonist administration improved motor recovery and reduced cognitive decline.
- CCR5-Δ32 mutation carriers showed enhanced neurological and cognitive recovery.
Conclusions:
- CCR5 is a significant therapeutic target for neural repair in stroke and TBI.
- CCR5 is the first reported gene associated with enhanced recovery in human stroke.
- CCR5 modulation offers a promising strategy for improving outcomes after brain injury.
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