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Updated: Jan 28, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
SnapShot: Cancer Immunotherapy with Oncolytic Viruses
Shashi Gujar1, John Bell2, Jean-Simon Diallo2
1Departments of Pathology, Biology, and Microbiology & Immunolgy, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Abstract:
Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.
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