Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.1K
Imprinting01:22

Imprinting

11.1K
Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
11.1K
Genomics02:02

Genomics

40.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.4K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
Physiological Barriers01:25

Physiological Barriers

5.2K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.2K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

15.9K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental defects revealed by modelling PWS in mice.

Disease models & mechanisms·2026
Same author

Traumatic life experiences during critical periods lead to diverse developmental trajectories.

Cell reports. Medicine·2026
Same author

Wnt4 as a signal coordinates DNA methylation and acetylation to determine germ line fate.

Developmental biology·2026
Same author

Neuroimmune interactions in sleep regulation: Epigenetic interfaces between microglia and T cells in brain homeostasis and dysfunction.

Sleep medicine reviews·2026
Same author

How Imprinted Genes Shape Nurturing Behaviours and Neural Circuits.

Brain, behavior and evolution·2026
Same author

ZFP57 is a regulator of postnatal growth and life-long health.

Nature communications·2026

Related Experiment Video

Updated: Jan 28, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

7.0K

Genomic Imprinting and Physiological Processes in Mammals.

Valter Tucci1, Anthony R Isles2, Gavin Kelsey3

  • 1Department of Neuroscience and Brain Technologies - Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy.

Cell
|February 23, 2019
PubMed
Summary

Genomic imprinting, an epigenetic phenomenon in mammals, uniquely expresses parental alleles, influencing traits and brain functions. This review covers key milestones and mechanisms of imprinted genes in development and disease.

More Related Videos

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K
Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm
09:23

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Published on: January 28, 2011

17.9K

Related Experiment Videos

Last Updated: Jan 28, 2026

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces
06:14

Multiscale Structures Aggregated by Imprinted Nanofibers for Functional Surfaces

Published on: September 11, 2018

7.0K
A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals
07:40

A Noninvasive Hair Sampling Technique to Obtain High Quality DNA from Elusive Small Mammals

Published on: March 13, 2011

21.4K
Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm
09:23

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm

Published on: January 28, 2011

17.9K

Area of Science:

  • Genetics
  • Epigenetics
  • Developmental Biology

Background:

  • Mammals possess two sets of chromosomes, inheriting genetic material from both parents.
  • Genomic imprinting is a notable exception, involving parent-specific allele expression crucial for mammalian physiology.
  • Imprinted genes, identified through epigenetic studies, regulate gene expression based on parental origin.

Purpose of the Study:

  • To review significant advancements in the field of genomic imprinting.
  • To discuss the mechanisms and biological systems influenced by imprinted genes.
  • To highlight the role of genomic imprinting in brain function and associated diseases.

Main Methods:

  • Literature review of key milestones in genomic imprinting research.
  • Analysis of established and emerging mechanisms of genomic imprinting.
  • Synthesis of current understanding regarding imprinted genes' roles in physiological systems.

Main Results:

  • Genomic imprinting is a well-established epigenetic mechanism influencing phenotypic expression.
  • Imprinted genes play a critical role in mammalian development and physiology.
  • Emerging evidence indicates a substantial impact of genomic imprinting on brain functions and neurological disorders.

Conclusions:

  • Genomic imprinting is a fundamental epigenetic process with broad physiological implications.
  • Further research into imprinted genes is essential for understanding brain development and disease.
  • Understanding imprinting mechanisms offers potential therapeutic targets for imprinting-related disorders.