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Related Concept Videos

The Electromagnetic Spectrum02:37

The Electromagnetic Spectrum

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The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
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The Electromagnetic Spectrum01:24

The Electromagnetic Spectrum

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Electromagnetic waves are categorized according to their wavelengths and frequencies, giving the electromagnetic spectrum. These waves are classified as radio, infrared, ultraviolet, etc. Radio waves refer to electromagnetic radiation with wavelengths ranging from millimeters to kilometers. Radio waves are commonly used for audio communications (i.e., radios) and typically result from an alternating current in the wires of a broadcast antenna. They cover a broad wavelength range and are used...
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IR Spectrum01:19

IR Spectrum

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When infrared (IR) radiation passes through a molecule, the bonds stretch or bend by absorbing the radiation. This absorption creates the molecule's absorption spectrum, which is the plot of its percentage transmittance versus wavenumber.
Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0%...
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Mass Spectrum01:23

Mass Spectrum

4.5K
A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ratio (m/z). The plot's x-axis represents the ratio of the mass of the charged fragment to the number of charges it carries. The y axis of the plot represents the relative abundance of each charged species. The relative abundance is calculated from the signal intensity of each charged species recorded at the detector. The most intense signal (the...
4.5K
UV–Vis Spectrum01:30

UV–Vis Spectrum

2.1K
When light passes through a substance, a portion of the light is absorbed while the remaining light is reflected or transmitted. If the molecule absorbs light between the wavelengths of 180–400 nm range, the UV spectrum is obtained, and if it absorbs light in the 400–780 nm wavelength range, the visible spectrum is obtained.     
The UV–Vis spectrum of a molecule is the plot of its absorbance versus wavelength. The plot is drawn by taking molar...
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The Antiviral System of Bacteria and Archaea: CRISPR01:23

The Antiviral System of Bacteria and Archaea: CRISPR

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CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
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Related Experiment Video

Updated: Jan 28, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Drug repurposing for new, efficient, broad spectrum antivirals.

Moisés García-Serradilla1, Cristina Risco1, Beatriz Pacheco1

  • 1Cell Structure Laboratory, National Center for Biotechnology, National Research Council, CNB-CSIC, Darwin 3, UAM, campus de Cantoblanco, 28049 Madrid, Spain.

Virus Research
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Drug repurposing offers a fast track to discover new antiviral therapies for emerging viruses. This review highlights promising candidates and strategies for understanding their action and resistance mechanisms.

Keywords:
AntiviralsDrug repurposingVirus

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Area of Science:

  • Virology
  • Pharmacology
  • Drug Discovery

Background:

  • Emerging viruses pose a significant global health threat, necessitating rapid development of effective treatments.
  • While vaccine development is crucial, immediate therapeutic options are vital during epidemics.
  • Repurposing existing, clinically tested drugs offers a accelerated pathway for identifying novel antiviral interventions.

Purpose of the Study:

  • To review recent advancements in identifying broad-spectrum antivirals through drug repurposing.
  • To explore promising drug candidates with potential antiviral activities.
  • To propose strategies for elucidating mechanisms of action and understanding antiviral resistance.

Main Methods:

  • High-throughput screening of clinically approved compounds.
  • Literature review of recent drug repurposing efforts for antiviral discovery.
  • Analysis of potential antiviral candidates and resistance development.

Main Results:

  • Drug repurposing enables rapid identification of existing therapeutics with new antiviral functions.
  • Several promising drug candidates have emerged from screening and repurposing initiatives.
  • Understanding mechanisms and resistance is key to successful antiviral deployment.

Conclusions:

  • Drug repurposing is a viable and efficient strategy for discovering urgently needed antiviral treatments.
  • Further research into mechanisms and resistance will optimize the use of repurposed antivirals.
  • This approach can significantly shorten the timeline for bringing effective therapies to patients.