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Updated: Jan 28, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
Precursors of Dimethylnitrosamine in Fried Bacon
J I Gray1, M E Collins1, B MacDONALD1
1Department of Food Science, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
Abstract:
Various compounds, all of which are endogenous to bacon systems, were investigated as precursors of dimethylnitrosamine. Low moisture model system studies indicated that dimethylamine and sarcosine were the major contributors to dimethylnitrosamine formation. Under conditions normally encountered in pan-frying of bacon, choline-containing compounds and sarcosine produced measurable quantities of this N-nitrosamine. It was also apparent that sarcosine under conditions of the experiment is a more probable precursor of dimethylnitrosamine. Up to 80% of the N-nitrosamine produced during the frying process was lost in the vapor.
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