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High-frequency repetitive transcranial magnetic stimulation (rTMS) improves neurocognitive function in bipolar
Lin-Lin Yang1, Dong Zhao2, Lan-Lan Kong1
1Institute of Mental Health, Hebei Medical University, Shijiazhuang, 050031, China; Department of Psychiatry, First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.
Journal of Affective Disorders
|February 24, 2019
Summary
Repetitive transcranial magnetic stimulation (rTMS) can enhance cognitive function in bipolar disorder (BD) patients. This short-term intervention improved specific memory and fluency scores without significant side effects.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Bipolar disorder (BD) is characterized by significant neurocognitive impairments.
- Repetitive transcranial magnetic stimulation (rTMS) is a potential therapeutic tool for psychiatric disorders.
- The efficacy of rTMS in improving cognitive function in BD patients is not well-established.
Purpose of the Study:
- To investigate the effects of rTMS on cognitive function in patients with bipolar disorder.
- To explore the potential of rTMS as an intervention for neurocognitive deficits in BD.
Main Methods:
- Fifty-two BD patients were randomized into active or sham rTMS groups.
- Active rTMS involved 25,000 stimuli over the left dorsolateral prefrontal cortex for 10 days.
- Cognitive function was assessed using the MATRICS Consensus Cognitive Battery (MCCB) and other scales.
Main Results:
- High-frequency rTMS significantly improved scores on the Wechsler Memory Scale-III Spatial Span.
- The MCCB Category Fluency subtest scores also showed improvement after rTMS.
- No significant adverse effects were reported, and no changes in depression or mania scores were observed.
Conclusions:
- Short-term application of rTMS demonstrates potential for improving cognitive function in bipolar disorder.
- rTMS may be a viable non-pharmacological approach to address cognitive deficits in BD.
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