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Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies

Sofia Melo Pereira1,2, Rui Ribeiro3,4, Elsa Logarinho5,6,7

  • 1Ageing and Aneuploidy Laboratory, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal. spereira@ibmc.up.pt.

International Journal of Molecular Sciences
|February 24, 2019
PubMed

Insights

This study explores anti-aging therapies like senolytics and cellular reprogramming. It proposes modulating mitotic competence as a novel strategy to slow aging and restore epigenetic landscape.

Area of Science:

  • Gerontology and Cellular Biology
  • Epigenetics and Aging Research

Background:

  • Current anti-aging therapies focus on senescence and epigenetic drift.
  • Senolytics eliminate senescent cells, while reprogramming reverts cells to pluripotency.

Purpose of the Study:

  • To review progress and challenges in senolytic and reprogramming anti-aging therapies.
  • To propose modulating mitotic competence as an alternative anti-aging strategy.

Main Methods:

  • Review of current senolytic and cellular reprogramming approaches.
  • Discussion of recent findings on mitotic shutdown and aneuploidy in senescence.
  • Conceptual proposal for modulating mitotic competence.

Main Results:

  • Senolytic and reprogramming therapies face significant challenges.
  • Mitotic shutdown and aneuploidy impact cellular senescence.
  • Modulating mitotic competence may offer a new anti-aging avenue.

Conclusions:

  • A regulated increase in mitotic competence could overcome limitations of current anti-aging methods.
  • This approach may decelerate senescence and restore the epigenetic landscape.
  • Mitotic competence modulation presents a promising alternative strategy for aging delay.
Keywords:
agingcell cycle fitnesscellular reprogrammingcellular senescence

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