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Linking Cellular Morphogenesis with Antifungal Treatment and Susceptibility in Candida Pathogens

Jehoshua Sharma1, Sierra Rosiana2, Iqra Razzaq3

  • 1Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada. jehoshua@uoguelph.ca.

Journal of Fungi (Basel, Switzerland)
|February 24, 2019
PubMed

Insights

Candida morphogenesis, its link to virulence, and antifungal drug resistance are reviewed. Targeting this fungal trait offers a novel therapeutic strategy against opportunistic fungal infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Fungal infections, particularly by *Candida* species, are a significant cause of mortality.
  • Morphogenesis (shape-shifting) in *Candida* is a key virulence factor linked to disease severity.
  • Understanding morphogenesis is crucial for developing effective antifungal treatments.

Purpose of the Study:

  • To review the intricate relationship between *Candida* morphogenesis and antifungal drug resistance.
  • To explore how antifungal drugs influence fungal morphology in both susceptible and resistant strains.
  • To discuss targeting morphogenesis as a novel anti-virulence strategy.

Main Methods:

  • Literature review of studies on *Candida* morphogenesis, virulence, and antifungal drug interactions.
  • Analysis of shared signaling pathways mediating morphogenesis and drug response.
  • Examination of the link between morphology, drug resistance, and biofilm formation.

Main Results:

  • Antifungal therapeutics can modulate *Candida* morphogenesis, impacting drug susceptibility.
  • Shared signaling pathways connect morphogenesis, drug response, and resistance mechanisms.
  • *Candida* morphology is closely associated with drug resistance and biofilm development.

Conclusions:

  • *Candida* morphogenesis is a critical virulence trait intertwined with antifungal drug resistance.
  • Targeting fungal morphogenesis presents a promising avenue for novel anti-virulence therapies.
  • Further research into these connections can lead to improved treatment strategies for fungal infections.
Keywords:
Antifungal drug resistanceAntifungal drugsCandidaFungal morphogenesisFungal pathogens

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