Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Permeability of Concrete01:25

Permeability of Concrete

502
Permeability in the context of concrete refers to how easily liquids or gases can pass through the material. This quality is crucial for assessing the water-tightness and durability of concrete structures and their resistance to chemical attacks. Concrete permeability can be determined through comparative laboratory tests. These tests typically involve sealing a concrete specimen from the sides, applying water pressure to the top surface with pressure, and measuring the amount of water passing...
502
Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

4.2K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
4.2K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

9.8K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
9.8K
Magnetic Susceptibility and Permeability01:31

Magnetic Susceptibility and Permeability

2.4K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
Factors Affecting Drug Distribution: Tissue Permeability01:30

Factors Affecting Drug Distribution: Tissue Permeability

647
The drug distribution process within the human body is a complex interplay of various physicochemical properties inherent to the drugs. These properties, including molecular size, ionization degree, partition coefficient, and stereochemical nature, significantly impact how drugs permeate biological membranes to reach their target tissues.
Small molecules with a molecular weight below 500 to 600 Daltons can easily pass through the capillary membrane, gaining access to different tissues. Larger...
647
Structures of Solids02:22

Structures of Solids

17.7K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentiating Etiologies of Pain in the Presence of Dorsal Arachnoid Web: A Case Report.

Pain medicine case reports·2026
Same author

Brassinolide and β-Sitosterol Interleaflet Diffusion in an Asymmetric Plant Model Membrane.

The journal of physical chemistry letters·2026
Same author

The AAHKS Clinical Research Award: Maximizing Bearing Size Markedly Reduces Dislocations in Primary Total Hip Arthroplasty.

The Journal of arthroplasty·2026
Same author

CDK5-p25 Peptide Inhibitor Samples an Intrinsically Disordered Ensemble in Solution.

The journal of physical chemistry. B·2026
Same author

Endoscopic resection of knosp grade 0-2 growth hormone-secreting pituitary adenomas with routine medial cavernous sinus wall excision.

Acta neurochirurgica·2026
Same author

Design, Preclinical Evaluation, and Clinical Translation of [68Ga]Ga/[177Lu]Lu-JH120061, A Novel Radiopharmaceutical Targeting CXCR4.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Related Experiment Video

Updated: Jan 28, 2026

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
07:18

Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

Published on: January 16, 2019

10.2K

Structure and Permeability of Ceramide Bilayers and Multilayers.

Eric Wang, Jeffery B Klauda

    The Journal of Physical Chemistry. B
    |February 24, 2019
    PubMed
    Summary

    This study models the stratum corneum barrier using ceramides. Longer ceramide chains and specific structures influence skin barrier thickness, lipid arrangement, and permeability to molecules like ethanol.

    Area of Science:

    • Biophysics
    • Materials Science
    • Computational Chemistry

    Background:

    • The stratum corneum (SC) acts as a crucial skin barrier, with ceramides (Cer) forming its structural basis.
    • Understanding ceramide structures is key to elucidating SC barrier function and permeability.

    Purpose of the Study:

    • To simulate and analyze simple ceramide models to understand their structural properties.
    • To investigate the effects of ceramide chain length and hydroxylation on bilayer properties.
    • To assess the permeability of ceramide bilayers to ethanol.

    Main Methods:

    • Molecular dynamics simulations using the CHARMM36 force field.
    • Simulation of pure ceramide lamellae, including single bilayers and CerEOS double layers.
    • Umbrella sampling simulations to calculate the potential of mean force (PMF) for ethanol penetration.

    More Related Videos

    Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
    08:26

    Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

    Published on: October 31, 2017

    9.7K
    Inkjet-printed Polyvinyl Alcohol Multilayers
    05:11

    Inkjet-printed Polyvinyl Alcohol Multilayers

    Published on: May 11, 2017

    13.1K

    Related Experiment Videos

    Last Updated: Jan 28, 2026

    Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
    07:18

    Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers

    Published on: January 16, 2019

    10.2K
    Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death
    08:26

    Saturated Fatty Acids Induce Ceramide-associated Macrophage Cell Death

    Published on: October 31, 2017

    9.7K
    Inkjet-printed Polyvinyl Alcohol Multilayers
    05:11

    Inkjet-printed Polyvinyl Alcohol Multilayers

    Published on: May 11, 2017

    13.1K

    Main Results:

    • Ceramide chain length significantly impacts SC bilayer thickness and interdigitation.
    • Hydroxylation enhances hydrogen bonding within ceramide bilayers.
    • CerEOS exhibits unique double-layer structures and higher surface area per lipid, influencing clustering.
    • Ethanol permeability is significantly reduced by longer ceramide chain lengths, despite disordered bilayer centers.

    Conclusions:

    • Ceramide structure, particularly chain length and hydroxylation, critically dictates skin barrier properties.
    • Simulated ceramide models provide valuable insights into SC lipid organization and permeability.
    • These findings serve as a foundation for more complex SC mixture simulations.