Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.0K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.0K
Convergent Evolution01:54

Convergent Evolution

32.8K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
32.8K
Eukaryotic Evolution01:24

Eukaryotic Evolution

40.8K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
40.8K
Synteny and Evolution02:31

Synteny and Evolution

3.8K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.8K
Anatomy of the Heart01:27

Anatomy of the Heart

119.7K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.7K
Natural and Artificial Concepts01:24

Natural and Artificial Concepts

559
In psychology, concepts can be divided into two categories: natural and artificial. Natural concepts are formed through direct or indirect experiences. For example, consider the concept of snow. If you live in a place with regular snowfall, such as Essex Junction, Vermont, you know snow through direct experiences. You’ve seen it fall, touched it, shoveled it, and played in it. You recognize its texture, appearance, and even its smell. In contrast, if you live on an island like Saint...
559

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Assessment of Hybrid Conduits for Biomedical Applications-A Pilot Study.

Polymers·2026
Same author

Successful EXCOR biventricular assist device weaning because of recovery in a child.

Perfusion·2025
Same author

In Vitro Assessment and Preliminary In Vivo Characterization of Innovative Hybrid Materials for Biomedical Applications.

Journal of biomedical materials research. Part A·2025
Same author

Systematic Review on Microtia: Current Knowledge and Future Directions.

Children (Basel, Switzerland)·2025
Same author

Polymeric Heart Valves: Do They Represent a Reliable Alternative to Current Prosthetic Devices?

Polymers·2025
Same author

Hybrid Materials for Vascular Applications: A Preliminary In Vitro Assessment.

Bioengineering (Basel, Switzerland)·2024

Related Experiment Video

Updated: Jan 28, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.2K

The Biocompatibility Challenges in the Total Artificial Heart Evolution.

Eleonora Dal Sasso1,2, Andrea Bagno3, Silvia T G Scuri2

  • 1Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua and Veneto Institute of Molecular Medicine, 35128 Padua, Italy; email: eleonora.dalsasso@studenti.unipd.it , gino.gerosa@unipd.it , laura.iop@unipd.it.

Annual Review of Biomedical Engineering
|February 24, 2019
PubMed
Summary

Total artificial hearts (TAHs) offer a vital option for end-stage heart failure, but material biocompatibility remains a challenge. This review analyzes TAH material issues and bioengineering solutions for improved hemocompatibility and device success.

Keywords:
calcificationhemocompatibilitymaterialsmicroorganism contaminationtotal artificial hearts

More Related Videos

Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

36.0K
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K

Related Experiment Videos

Last Updated: Jan 28, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.2K
Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

36.0K
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
08:49

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

Published on: May 11, 2018

9.9K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Limited therapeutic options exist for end-stage heart failure, making total artificial hearts (TAHs) a critical alternative when donors are unavailable.
  • Despite decades of development, TAH performance is hindered by poor biocompatibility of blood-contacting surfaces, leading to complications like hemocompatibility issues, calcification, and infections.
  • These material-related challenges have resulted in the failure of numerous TAH prototypes during preclinical testing.

Purpose of the Study:

  • To comprehensively analyze the pathophysiological events affecting materials used in current total artificial hearts (TAHs).
  • To illustrate bioengineering strategies aimed at preventing adverse material-related events in TAHs.
  • To outline key advancements toward developing a fully biocompatible TAH.

Main Methods:

  • Literature review of TAH development and material science.
  • Analysis of pathophysiological events impacting blood-contacting surfaces in TAHs.
  • Synthesis of bioengineering approaches to enhance TAH material biocompatibility.

Main Results:

  • Identified low hemocompatibility, calcification, and infection susceptibility as primary material-related failures in TAHs.
  • Detailed various bioengineering strategies, including surface modifications and advanced material selection, to mitigate these issues.
  • Highlighted progress in overcoming material limitations for TAH applications.

Conclusions:

  • Improving the biocompatibility of blood-contacting materials is paramount for successful TAH implantation.
  • Bioengineering innovations are crucial for addressing TAH material-related complications.
  • Significant steps are being made toward achieving fully biocompatible total artificial hearts for patients with end-stage heart failure.