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Related Experiment Video

Updated: Jan 28, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Spatial and Temporal Locomotor Learning in Mouse Cerebellum.

Dana M Darmohray¹, Jovin R Jacobs¹, Hugo G Marques¹

¹Champalimaud Neuroscience Program, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.

|February 24, 2019

Summary

Mice learn to adapt their walking on a split-belt treadmill, showing conserved locomotor learning across vertebrates. This adaptation relies on the cerebellum, not the cerebral cortex, and involves dissociable spatial and temporal components.

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Area of Science:

Neuroscience
Motor Control
Locomotion

Background:

Locomotion requires precise coordination of limbs and body.
Learned motor adaptations, like interlimb coordination changes, can be induced by altered sensory feedback, such as on split-belt treadmills.

Purpose of the Study:

To investigate locomotor learning and adaptation in mice using a split-belt treadmill.
To determine the neural substrates and circuit-level mechanisms underlying mouse locomotor adaptation.
To explore the conserved nature of locomotor adaptation across species.

Main Methods:

Split-belt treadmill training in mice.
Quantitative behavioral analysis of locomotion.
Lesion studies targeting the cerebellum and cerebral cortex.
Cell-type-specific chemogenetics.

Main Results:

Mice exhibit robust locomotor adaptation on a split-belt treadmill, specific to interlimb coordination.
Adaptation involves distinct spatial and temporal components that change at different rates.
Locomotor adaptation in mice is dependent on the intermediate cerebellum but not the cerebral cortex.
Spatial and temporal components of adaptation are dissociable at the circuit level.

Conclusions:

Mouse locomotor adaptation shares key features with human adaptation, suggesting a conserved mechanism across vertebrates.
The intermediate cerebellum is critical for split-belt adaptation, while the cerebral cortex is not essential.
Neural circuits underlying spatial and temporal aspects of motor learning are distinct and can be manipulated independently.