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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Published on: December 9, 2021
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Is Resolution the End of Inflammation?
Karen T Feehan1, Derek W Gilroy1
1Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JF, UK.
Trends in Molecular Medicine
|February 24, 2019
Summary
Understanding chronic inflammatory diseases requires exploring inflammation resolution. New research suggests immune activity continues after resolution, leading to adapted homeostasis, not just restoration.
Area of Science:
- Immunology
- Pathology
- Cellular Biology
Background:
- Chronic inflammatory and autoimmune diseases lack clear origins, with treatments focusing on halting inflammation.
- Emerging research highlights the potential of targeting inflammation resolution pathways.
Purpose of the Study:
- To investigate the immunological events occurring after the resolution of inflammation.
- To re-evaluate the concept of homeostasis in the context of innate immune responses.
Main Methods:
- Review of recent immunological studies on inflammation resolution.
- Analysis of cellular events and mediator functions during and after inflammation resolution.
Main Results:
- Inflammation resolution involves complex mediators regulating cellular events to clear inflammatory cells and restore tissue function.
- Post-resolution immunological activity alters tissue immune physiology.
Conclusions:
- The immune response to infection/injury extends beyond inflammation resolution.
- Tissue homeostasis may be better described as 'adapted homeostasis' due to persistent immunological alterations.
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