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Related Experiment Videos

Contrast media for angiography: effect on renal function.

C Cruz, H Hricak, F Samhouri

    Radiology
    |January 1, 1986
    PubMed
    Summary
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    Contrast material injection for severe peripheral vascular disease rarely causes acute kidney injury. When it occurs, it is typically reversible and linked to complicating factors like diabetes.

    Area of Science:

    • Radiology
    • Nephrology
    • Vascular Surgery

    Background:

    • Severe peripheral vascular disease necessitates advanced imaging techniques.
    • Translumbar aortography is a key diagnostic tool for evaluating vascular disease.
    • Contrast-induced nephropathy is a potential complication of iodinated contrast media.

    Purpose of the Study:

    • To assess the incidence and reversibility of acute renal failure following translumbar aortography.
    • To identify risk factors associated with contrast-induced nephropathy in patients with peripheral vascular disease.
    • To evaluate the impact of contrast media on renal function in a high-risk patient cohort.

    Main Methods:

    • 125 patients with severe peripheral vascular disease underwent translumbar aortography.

    Related Experiment Videos

  • Mean contrast dose: 65 ml of Angio Conray (31.2 g iodine).
  • Patient subgroups included those pretreated with mannitol (40) or furosemide (32); 38 patients had diabetes.

    • Main Results:

    • No significant reduction in renal function was observed across patient groups post-contrast administration.
    • Eleven diabetic patients with presumed diabetic nephropathy showed significant azotemia (creatinine ≥ 4 mg/dl).
    • Acute renal failure following contrast injection was uncommon and reversible in this cohort.

    Conclusions:

    • Acute renal failure from contrast material is infrequent and generally reversible.
    • Complicating factors, such as diabetes and azotemia, are strongly associated with contrast-induced nephropathy.
    • Careful patient selection and management can mitigate the risk of contrast-induced renal complications.