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1-Amino-2'-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae
Kelly M Craft1, Steven D Townsend2,3,4
1Department of Chemistry, Vanderbilt University, 7330 Stevenson Center, Nashville, TN, 37235, USA.
The Journal of Antibiotics
|February 24, 2019
Abstract:
2'-Fucosyllactose (2'-FL) is a ubiquitous oligosaccharide in human milk. Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria, a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to evaluate the potential of 2'-FL to serve as an antibacterial agent against Group B Streptococcus (GBS). While 2'-FL was devoid of any substantial antimicrobial or antibiofilm activity, conversion of 2'-FL to its reducing end β-amine provided a novel antibiofilm compound.