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Cluster headache in relation to different age groups.

Gian Camillo Manzoni1, Cecilia Camarda2, Antonio Genovese3

  • 1University of Parma, Parma, Italy. giancamillo.manzoni@unipr.it.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|February 24, 2019
PubMed
Summary
This summary is machine-generated.

Cluster headache (CH) typically affects middle-aged men. However, recent findings show CH can begin later in life or in childhood, with a shift in gender prevalence, suggesting hormonal influences.

Keywords:
Age at onsetCluster headacheEpidemiologyPrevalence

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Cluster headache (CH) is a primary headache disorder.
  • Historically, CH predominantly affects males in early to mid-adulthood.

Purpose of the Study:

  • To analyze the age of onset and gender distribution in cluster headache.
  • To explore potential hormonal influences on CH presentation across different age groups.

Main Methods:

  • Review of large case series of patients diagnosed with cluster headache.
  • Analysis of demographic data, specifically age at onset and gender.

Main Results:

  • CH onset after age 50 is not uncommon.
  • Onset before adolescence is rare.
  • Male predominance decreases in late-onset and early-onset CH.
  • Chronic CH predominantly affects females in later age groups.

Conclusions:

  • The changing gender ratio in CH across different age groups suggests a role for hormonal factors.
  • Estrogen's potential protective role in cluster headache warrants further investigation.