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The road less travelled: The efficacy of canine pluripotent stem cells

Dhanya V Menon1, Darshan Patel2, Chaitanya G Joshi3

  • 1P.D.Patel Institute of Applied Sciences, Charusat University, Changa, Gujarat, India; School of Regenerative Medicine (SORM), Manipal Academy of Higher Education, Bangalore, India.

Experimental Cell Research
|February 24, 2019
PubMed

Insights

Canine stem cells, including embryonic stem cells (cESCs) and induced pluripotent stem cells (ciPSCs), show promise for regenerative medicine. This review highlights their potential in both veterinary and human therapies by examining canine pluripotency pathways.

Area of Science:

  • Stem cell research
  • Regenerative medicine
  • Comparative genomics

Background:

  • Induced pluripotent stem cells (iPSCs) have advanced stem cell research.
  • Ensuring stem cell therapy safety requires suitable animal models.
  • Dogs are valuable models due to genomic and physiological similarity to humans.

Purpose of the Study:

  • To review canine pluripotency pathways.
  • To bridge the gap in utilizing canine stem cells for therapy.
  • To position dogs within the reprogramming landscape.

Main Methods:

  • Analysis of recent canine embryonic stem cell (cESC) and canine induced pluripotent stem cell (ciPSC) derivations.
  • Comparison of canine pluripotency pathways.
  • Review of existing canine gene therapy models.

Main Results:

  • Dogs offer unique advantages for disease modeling and stem cell therapy research.
  • Key differences in canine pluripotency pathways are identified.
  • Canine iPSCs present significant therapeutic potential.

Conclusions:

  • Canine stem cells hold great promise for veterinary and human medicine.
  • Further research into canine pluripotency pathways is warranted.
  • Canine iPSCs could revolutionize regenerative medicine in veterinary care.
Keywords:
Canine modelsDogEmbryonic stem cellsInduced pluripotent stem cellsPluripotency pathwaysRegenerative medicineReprogrammingStem cell therapy modelsVeterinary scienceciPSCs

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