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Related Experiment Video

Updated: Jan 28, 2026

Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
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PCI Alternative Using Sustained Exercise (PAUSE): Rationale and trial design.

Jonathan Myers1, Holly Fonda1, Minal Vasanawala1

  • 1Veterans Affairs Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University, United States of America.

Contemporary Clinical Trials
|February 24, 2019
PubMed
Summary
This summary is machine-generated.

Exercise therapy may offer a viable alternative to percutaneous coronary intervention (PCI) for improving coronary function and anatomy. The PAUSE trial investigates exercise as a cost-effective, non-invasive strategy for coronary artery disease (CAD) management.

Keywords:
Cardiac rehabilitationCoronary artery diseaseCost-effectivenessExerciseExercise testingPercutaneous coronary intervention

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Area of Science:

  • Cardiology
  • Preventive Medicine
  • Medical Imaging

Background:

  • Cardiovascular disease (CVD), particularly coronary artery disease (CAD), is a leading cause of mortality in the US.
  • Percutaneous coronary intervention (PCI) is a common but costly treatment for CAD, with questions arising about its overuse and cost-effectiveness.
  • Optimal medical therapy and exercise interventions are emerging as potential alternatives to PCI, offering physiological benefits and improved outcomes.

Purpose of the Study:

  • To evaluate exercise therapy as a non-invasive alternative to PCI for patients with CAD.
  • To compare the efficacy of a sustained exercise and lifestyle intervention versus PCI in improving coronary function and anatomy.
  • To demonstrate the utility of positron emission tomography/computed tomographic angiography (PET/CTA) in assessing exercise therapy's impact.

Main Methods:

  • The study, termed "PCI Alternative Using Sustained Exercise" (PAUSE), randomizes patients to either an exercise/lifestyle intervention group or a PCI group.
  • Coronary function and anatomy are assessed using non-invasive positron emission tomography combined with computed tomographic angiography (PET/CTA).

Main Results:

  • This section is to be filled once the study is completed and results are available.

Conclusions:

  • This section is to be filled once the study is completed and conclusions are drawn.