Rapidly growing, multifocal, benign choroid plexus tumor in an infant: case report

Area of Science:

• Pediatric Oncology
• Neuro-oncology
• Tumor Biology

Background:

• Choroid plexus papillomas (CPPs) are rare, benign tumors typically affecting young children.
• Most pediatric cases present with hydrocephalus, necessitating prompt intervention.
• The natural history of CPPs in children without hydrocephalus remains poorly understood.

Observation:

• A rare case of a neonate diagnosed with two intraventricular choroid plexus tumors without hydrocephalus.
• Initial imaging revealed agenesis of the corpus callosum and enhancing tumors in the third and left lateral ventricles.
• Sequential imaging demonstrated rapid tumor growth.

Findings:

• Both tumors were histologically confirmed as WHO grade I Choroid Plexus Papillomas.
• Surgical resection was performed on both tumors in the infant.
• Elevated mitotic rates were noted despite benign histological features.

Implications:

• This case highlights the importance of vigilant monitoring for pediatric intraventricular tumors, even in the absence of hydrocephalus.
• It contributes to the limited literature on the natural history and management of non-hydrocephalic CPPs in infants.
• Further research is needed to understand the growth patterns and optimal treatment strategies for such rare presentations.